Current Bioscience is an open-access peer-reviewed journal that publishes research articles in different fields of science, but with special focus on the field of microbiology and immunology including basic and clinical studies. We highlight the most significant advances in current topics of bioscience.
Most peptides have been discovered from natural sources or via combinatorial chemistry methods, but the International Union of Pure and Applied Chemistry’s one-letter symbolism for the names of amino acids facilitates the use of language as a novel source of potentially bioactive peptides…
Due to the continued growth of antibiotic-resistant Staphylococcus aureus strains, it is necessary to explore alternative targets for future therapeutic applications. For this reason, is important to understand the staphylococcal immune evasion mechanisms with a special focus on extracellular fibrinogen-binding protein (Efb) and Efb related proteins. Therefore, it was conducted a literature review to compile relevant information on this protein. It was found that Efb has three binding sites with biological relevance that could be used as therapeutic targets with specificity for fibrinogen, platelets, and complements. First, the fibrinogen-binding motifs also found in coagulase block neutrophil αMβ2 adherence to fibrinogen and attract fibrinogen to the bacterial surface, forming capsule-like structures that block phagocytosis…
To find new strategies, it is important to understand the mechanisms that Staphylococcus aureus uses to adapt to its host and how the host responds to the presence of staphylococcal cells. We have reviewed two studies of gene expression in Staphylococcus aureus during skin infections, one study using a rabbit skin infection model and ….
The phage display is a powerful technique to identify pathogenic binding sites implicated in autoimmune diseases (ADs). With chimeras of binding peptides can be identified amino acid residues implicated in the binding and defined more precisely the pathogenic epitope such as in the α3(IV)NC1 domain of Goodpasture disease. Epitope sharing….
The experience with SARS-CoV-2 that spread rapidly throughout the world makes us realize we need protocols to act quickly against emerging pathogens. The immune system of recovering patients provided protection against any pathogen by producing antibodies against immunogenic epitopes…
Molecular mimicry is one of the main mechanisms by which bacteria induce autoimmunity. It occurs when bacterial components have sequential or structural similarity with self-peptides inducing the activation of autoreactive T or B cells. Several bacteria can induce an autoimmune response by molecular mimicry mechanism..
Defensins are small cysteine-rich cationic peptides, found in a broad range of species in animal and plant kingdoms. It has been identified three sub-classes of defensins (e.g. α, β, and θ) which have conserved six cysteine signature. They play an important role as host defense peptides with activity against bacteria….